Human papillomavirus genome detection by in situ hybridization in fine-needle aspirates of metastatic lesions from head and neck squamous cell carcinomas.

@article{Umudum2005HumanPG,
  title={Human papillomavirus genome detection by in situ hybridization in fine-needle aspirates of metastatic lesions from head and neck squamous cell carcinomas.},
  author={Haldun Umudum and Turkan Atasever Rezanko and Filiz Dağ and Tugba Paksoy Dogruluk},
  journal={Cancer},
  year={2005},
  volume={105 3},
  pages={
          171-7
        }
}
BACKGROUND Patients with head and neck squamous cell carcinoma (HNSCC) often present with metastatic disease. The diagnosis of metastatic lesions usually is determined by fine-needle aspiration. Human papillomavirus (HPV) is now being considered as a causative agent in a subset of HNSCC. The objectives of this study were, first; to search for the presence of HPV DNA by in situ hybridization (ISH) in metastatic lesions from HNSCC using alcohol-fixed, archival, cytopathologic material; second, to… CONTINUE READING

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