Human papillomavirus early proteins and apoptosis

  title={Human papillomavirus early proteins and apoptosis},
  author={Qiong Cai and Liang Lv and Qian Shao and Xiao Li and Aiping Dian},
  journal={Archives of Gynecology and Obstetrics},
The human papillomavirus (HPV) associated apoptosis can be primarily attributed to some early proteins, such as E2, E5, E6, E7, and so on. Though these proteins have a low molecular size, they are capable to interact with a series of host cellular regulation proteins to induce or inhibit apoptosis. The oncoproteins E6 can inhibit the apoptosis mainly through p53 pathway. The E5 protein can protect cells from tumor necrosis factor-related apoptosis. The protein E2 protein have regulatory… CONTINUE READING

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Genetic and epigenetic changes of HPV 16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression

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