Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers.

@article{Gillison2006HumanPA,
  title={Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers.},
  author={M. Gillison},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 36},
  pages={
          5623-5
        }
}
  • M. Gillison
  • Published 2006
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Oropharyngeal squamous cell carcinomas are etiologically heterogeneous, with one subset attributable primarily to human papillomavirus (HPV) infection and another to alcohol and tobacco use. These subsets are clinically and molecularly distinct, and these distinctions extend to patient prognosis. 1 In this issue of the Journal of Clinical Oncology, Licitra et al 2 report that patients with HPV DNA–positive oropharyngeal cancers have an approximately 60% reduction in 5-year mortality when… Expand
115 Citations

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to establish the efficacy and toxicity of low dose chemoradiotherapy after induction chemotherapy in patients with locally advanced HPV+ oropharynx… Expand
ConditionsLocally Advanced HPV Positive Oropharynx Cancer
InterventionRadiation
Interventional Clinical Trial
This trial aims to directly compare a reduced radiation dose to the standard of care in HPVOPC for non-inferiority, thus allowing for direct comparison of outcomes between the two… Expand
ConditionsSquamous Cell Carcinomas
InterventionDrug, Radiation
[High-risk human papilloma virus associated oropharynx squamous cell carcinomas: clinical, biological implications and therapeutical perspectives].
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Human Papilloma Virus in Head and Neck Squamous Cell Cancer
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