Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers.

@article{Gillison2006HumanPA,
  title={Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers.},
  author={M. Gillison},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 36},
  pages={
          5623-5
        }
}
  • M. Gillison
  • Published 2006
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Oropharyngeal squamous cell carcinomas are etiologically heterogeneous, with one subset attributable primarily to human papillomavirus (HPV) infection and another to alcohol and tobacco use. These subsets are clinically and molecularly distinct, and these distinctions extend to patient prognosis. 1 In this issue of the Journal of Clinical Oncology, Licitra et al 2 report that patients with HPV DNA–positive oropharyngeal cancers have an approximately 60% reduction in 5-year mortality when… Expand
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115 Citations
Highly Influential Citations
4
Background Citations
33
Methods Citations
3
Results Citations
4

Paper Mentions

Interventional Clinical Trial
Quarterback 2b - Sequential Therapy With Reduced Dose Chemoradiotherapy for HPV Oropharynx Cancer
The purpose of this study is to establish the efficacy and toxicity of low dose chemoradiotherapy after induction chemotherapy in patients with locally advanced HPV+ oropharynx… Expand
ConditionsLocally Advanced HPV Positive Oropharynx Cancer
InterventionRadiation
Icahn School of Medicine at Mount Sinai
April 2016 - April 2023
Interventional Clinical Trial
The Quarterback Trial: Reduced Dose Radiotherapy for HPV+ Oropharynx Cancer
This trial aims to directly compare a reduced radiation dose to the standard of care in HPVOPC for non-inferiority, thus allowing for direct comparison of outcomes between the two… Expand
ConditionsSquamous Cell Carcinomas
InterventionDrug, Radiation
Icahn School of Medicine at Mount Sinai
September 2012 - December 2021

115 Citations

Citation Type

Citation Type

Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: Clinical Considerations
Clinical Management of HPV-Related Oropharyngeal Cancer
HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS.
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Predictive value of epigenetic alterations in head and neck squamous cell carcinoma
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Human Papilloma Virus (HPV) in head and neck region: review of literature L'infezione da papilloma virus umano (HPV) nel distretto cervico-facciale: revisione della letteratura
[High-risk human papilloma virus associated oropharynx squamous cell carcinomas: clinical, biological implications and therapeutical perspectives].
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Human Papilloma Virus in Head and Neck Squamous Cell Cancer
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Human Papilloma Virus in Head and Neck Squamous Cell
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