Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers.

@article{Gillison2006HumanPA,
  title={Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers.},
  author={Maura Gillison},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 36},
  pages={
          5623-5
        }
}
  • M. Gillison
  • Published 20 December 2006
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Oropharyngeal squamous cell carcinomas are etiologically heterogeneous, with one subset attributable primarily to human papillomavirus (HPV) infection and another to alcohol and tobacco use. These subsets are clinically and molecularly distinct, and these distinctions extend to patient prognosis. 1 In this issue of the Journal of Clinical Oncology, Licitra et al 2 report that patients with HPV DNA–positive oropharyngeal cancers have an approximately 60% reduction in 5-year mortality when… 
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117 Citations

Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: Clinical Considerations
TLDR
The purpose of this chapter is to review the epidemiology as well as clinical aspects of diagnosis and treatment for HPV-associated head and neck squamous cell carcinomas, particularly oropharyngeal squamouscell carcinoma (OPC).
Clinical Management of HPV-Related Oropharyngeal Cancer
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The demographics and prognosis of locally advanced head and neck squamous cell cancer (HNSCC) have changed dramatically over the past two decades and evidence shows that HPV16 is the molecular cause that mechanistically drives the development and viability of the cancer cells.
HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS.
TLDR
Experimental data supporting the view that HPV-associated HNSCC deserves to be recognized as a distinct disease in the clinic and as such needs to be appropriately diagnosed are focused on.
[Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications].
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It is shown that the distinct biological behavior of the HPV-related subset of oropharyngeal tumors results in a more favorable prognosis, and it will be mandatory to consider and stratify HPV status in the design of prospective clinical trials in the future.
Predictive value of epigenetic alterations in head and neck squamous cell carcinoma
TLDR
This review provides a comprehensive summary of alterations of the epigenome in head and neck squamous cell carcinoma with a focus on the methylome (hypomethylation and hypermethylation) and its predictive value in the evaluation of pathologic states and clinical outcome, or monitoring response rates to certain therapies.
Use of combined molecular biomarkers for prediction of clinical outcomes in locally advanced tonsillar cancers treated with chemoradiotherapy alone
TLDR
To which extent the virus infection by itself, and/or the altered cell cycle proteins, contributes to prognosis in locally advanced tonsillar squamous cell carcinomas treated with concurrent chemoradiotherapy (CCRT) alone is investigated.
Human Papilloma Virus (HPV) in head and neck region: review of literature L'infezione da papilloma virus umano (HPV) nel distretto cervico-facciale: revisione della letteratura
TLDR
This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors for transmission, clinical signifi cance and prophylactic strategies.
Human Papilloma Virus in Head and Neck Squamous Cell Cancer
TLDR
HPV infection has a significant impact on Head and Neck Squamous Cell Carcinomas, and despite HPV-16 stronger impact, HPV-18 is more likely to cause malignant degeneration in such cancers amongst some communities.
What are the implications of human papillomavirus status in oropharyngeal tumors for clinical practice?
  • J. Klozar, R. Tachezy
  • Medicine, Biology
    Current opinion in otolaryngology & head and neck surgery
  • 2014
TLDR
The present review discusses the standardization of detection methods suitable for clinical use and the differences in predictive parameters between patients with HPV-positive and HPV-negative tumors.
The Role of Human Papillomaviruses in the Aetiopathogenesis of Head and Neck Cancer in South Asia, and Approaches to Treatment
TLDR
RNA interference (RNAi), which has shown great promise as a highly specific therapy for other diseases, has potential for treating HPV-associated HNC, especially if disease progression is dependent on the continual expression of HPV oncogenes.
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