Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers.

@article{Gillison2006HumanPA,
  title={Human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: implications for clinical research in head and neck cancers.},
  author={Maura Gillison},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 36},
  pages={
          5623-5
        }
}
  • M. Gillison
  • Published 20 December 2006
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Oropharyngeal squamous cell carcinomas are etiologically heterogeneous, with one subset attributable primarily to human papillomavirus (HPV) infection and another to alcohol and tobacco use. These subsets are clinically and molecularly distinct, and these distinctions extend to patient prognosis. 1 In this issue of the Journal of Clinical Oncology, Licitra et al 2 report that patients with HPV DNA–positive oropharyngeal cancers have an approximately 60% reduction in 5-year mortality when… 
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TLDR
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What are the implications of human papillomavirus status in oropharyngeal tumors for clinical practice?
  • J. Klozar, R. Tachezy
  • Medicine, Biology
    Current opinion in otolaryngology & head and neck surgery
  • 2014
TLDR
The present review discusses the standardization of detection methods suitable for clinical use and the differences in predictive parameters between patients with HPV-positive and HPV-negative tumors.
The Role of Human Papillomaviruses in the Aetiopathogenesis of Head and Neck Cancer in South Asia, and Approaches to Treatment
TLDR
RNA interference (RNAi), which has shown great promise as a highly specific therapy for other diseases, has potential for treating HPV-associated HNC, especially if disease progression is dependent on the continual expression of HPV oncogenes.
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