Human papillomavirus and cervical cancer

@article{Schiffman2007HumanPA,
  title={Human papillomavirus and cervical cancer},
  author={M. Schiffman and P. Castle and J. Jeronimo and A. C. Rodr{\'i}guez and S. Wacholder},
  journal={The Lancet},
  year={2007},
  volume={370},
  pages={890-907}
}
  • M. Schiffman, P. Castle, +2 authors S. Wacholder
  • Published 2007
  • Medicine
  • The Lancet
  • Cervical cancer is the second most common cancer in women worldwide, and knowledge regarding its cause and pathogenesis is expanding rapidly. Persistent infection with one of about 15 genotypes of carcinogenic human papillomavirus (HPV) causes almost all cases. There are four major steps in cervical cancer development: infection of metaplastic epithelium at the cervical transformation zone, viral persistence, progression of persistently infected epithelium to cervical precancer, and invasion… CONTINUE READING

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