Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis.

@article{Shin2009HumanPE,
  title={Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis.},
  author={Myeong-Kyun Shin and Scott Balsitis and Tiffany Brake and Paul F Lambert},
  journal={Cancer research},
  year={2009},
  volume={69 14},
  pages={5656-63}
}
The E7 oncoprotein of the high-risk human papillomaviruses (HPV) is thought to contribute to cervical carcinogenesis at least in part by abrogating cell cycle regulation. E7 can dysregulate the cell cycle through its interaction with several cellular proteins including the retinoblastoma suppressor protein pRb, as well as the cyclin-dependent kinase inhibitor p21(Cip1). Inactivation of pRb in cervical epithelia is not sufficient to explain the ability of E7 to cause cervical cancers in… CONTINUE READING

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protein through the ubiquitinproteasome pathway

  • SJ Balsitis, J Sage, S Duensing, K Munger, T Jacks, PF Lambert
  • 2009

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