Human papillomavirus E6/E7 oncogenes promote mouse ear regeneration by increasing the rate of wound re-epithelization and epidermal growth.

@article{Valencia2008HumanPE,
  title={Human papillomavirus E6/E7 oncogenes promote mouse ear regeneration by increasing the rate of wound re-epithelization and epidermal growth.},
  author={Concepci{\'o}n Valencia and Jos{\'e} Bonilla-Delgado and Katarzyna Oktaba and Rodolfo Ocadiz-Delgado and Patricio Gariglio and Luis Covarrubias},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 12},
  pages={2894-903}
}
Mammals have limited regeneration capacity. We report here that, in transgenic mice (Tg(bK6-E6/E7)), the expression of the E6/E7 oncogenes of human papilloma virus type 16 (HPV16) under the control of the bovine keratin 6 promoter markedly improves the mouse's capacity to repair portions of the ear after being wounded. Increased repair capacity correlates with an increased number of epidermal proliferating cells. In concordance with the expected effects of the E6 and E7 oncogenes, levels of p53… CONTINUE READING

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