Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells.

@article{Oh2009HumanPE,
  title={Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells.},
  author={J Oh and Su-Hyeong Kim and Yun-il Lee and Miran Seo and So-young Kim and Yong Sang Song and W Kim and Y. -S. Juhnn},
  journal={Carcinogenesis},
  year={2009},
  volume={30 1},
  pages={141-9}
}
Human papillomavirus (HPV) is the major cause of uterine cervical cancer, but the role of the HPV E5 in carcinogenesis is not clearly understood. Prostaglandins are known to contribute to carcinogenesis of cervical cancer, and we therefore investigated the effect of HPV16 E5 on the expression of prostaglandin E2 (PGE2) receptors and underlying mechanisms. Stable expression of the E5 induced expression of the EP4 subtype of PGE2 receptors in C33A cervical cancer cells, and transfection of E5… CONTINUE READING
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