Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis.


L83V-related variants of human papillomavirus (HPV) 16 E6, exemplified by the Asian-American variant Q14H/H78Y/L83V, were shown to be more prevalent than E6 prototype in progressing lesions and cervical cancer. We evaluated functions relevant to carcinogenesis for the E6 variants L83V, R10/L83V and Q14H/H78Y/L83V as well as the prototype in a model of human… (More)
DOI: 10.1016/j.virol.2008.09.036


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