Human papillomavirus: E6 and E7 oncogenes.

@article{Boulet2007HumanPE,
  title={Human papillomavirus: E6 and E7 oncogenes.},
  author={Ga{\"e}lle Boulet and Caroline A.J. Horvath and Davy Vanden Broeck and Shaira Sahebali and Johannes J. Bogers},
  journal={The international journal of biochemistry & cell biology},
  year={2007},
  volume={39 11},
  pages={
          2006-11
        }
}
The recognition of a causal relationship between human papillomaviruses and cancer almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the description of the main mediators of HPV-induced carcinogenesis, the viral proteins E6 and E7. These oncoproteins show a remarkable pleiotropism in binding host-cell proteins, with the tumour suppressor genes p53 and pRb as their major targets. These interactions induce proliferation, immortalization and malignant… CONTINUE READING

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