Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1

@article{Cordes2007HumanPT,
  title={Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1},
  author={Nils Cordes and Steven L Frick and Thomas B Brunner and Christian Pilarsky and Robert Gr{\"u}tzmann and Bence Sipos and Guenter Kloeppel and W. Gillies Mckenna and Eric J. Bernhard},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={6851-6862}
}
Caveolin-1 (Cav-1) is an integral transmembrane protein and a critical component in interactions of integrin receptors with cytoskeleton-associated and signaling molecules. Since integrin-mediated cell adhesion generates signals conferring radiation resistance, we examined the effects of small interfering RNA-mediated knockdown of Cav-1 alone or in combination with β1-integrin or focal adhesion kinase (FAK) on radiation survival and proliferation of pancreatic carcinoma cell lines. Irradiation… CONTINUE READING
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