Human pancreatic islet endothelial cells express coxsackievirus and adenovirus receptor and are activated by coxsackie B virus infection.

@article{Zanone2007HumanPI,
  title={Human pancreatic islet endothelial cells express coxsackievirus and adenovirus receptor and are activated by coxsackie B virus infection.},
  author={Maria M. Zanone and Enrica Favaro and Elena Ferioli and Guo Cai Huang and Nigel Klein and Paolo Cavallo Perin and Mark Peakman and Pier Giulio Conaldi and Giovanni Camussi},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 12},
  pages={3308-17}
}
Enteroviruses, such as the coxsackievirus (CV) group, have been linked to the induction of inflammatory and autoimmune diseases. Virus tropism and tissue access are modulated by endothelial cells. To examine the susceptibility of microvascular endothelial cells (MECs) derived from pancreatic islets to infection with CV group B (CVB), purified cultured human islet MECs were infected with CVB-4 strain, and the immunological phenotype of the infected cells was analyzed. CVB-4 persistently infected… CONTINUE READING