Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production.

@article{Rabinovitch1994HumanPI,
  title={Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production.},
  author={Alex Rabinovitch and Wilma L. Suarez-Pinzon and Ken Strynadka and Ralph Schulz and Jonathan Rt Lakey and Garth L. Warnock and Ray V. Rajotte},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={79 4},
  pages={1058-62}
}
The inflammatory cytokines, interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma are cytotoxic to human islet beta-cells in vitro. To determine the possible role of nitric oxide (NO) as a mediator of cytokine-induced islet beta-cell destruction, we studied the relationships between NO production and destruction of human pancreatic islet… CONTINUE READING