Human pancreatic acinar cells do not respond to cholecystokinin.

  title={Human pancreatic acinar cells do not respond to cholecystokinin.},
  author={Baoan Ji and Yan Bi and Diane Simeone and Richard M. Mortensen and Craig D. Logsdon},
  journal={Pharmacology & toxicology},
  volume={91 6},
Pancreatic secretion can be influenced by cholecystokinin (CCK) either directly via actions on acinar cells or indirectly via actions on nerves. The presence and functional roles of CCK receptors on human pancreatic acinar cells remains unclear. In the current study human pancreatic acini were isolated and then treated with CCK-8, gastrin and/or carbachol. Functional parameters were measured including intracellular [Ca2+] and amylase secretion. It was observed that human acini did not respond… CONTINUE READING


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