Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells

@article{Zheng2003HumanPP,
  title={Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells},
  author={Yong-Hui Zheng and Hai-feng Yu and B Matija Peterlin},
  journal={Nature Cell Biology},
  year={2003},
  volume={5},
  pages={611-618}
}
In the mouse, replication of human immunodeficiency virus type 1 (HIV) is blocked at the levels of entry, transcription and assembly. For the latter effect, the amounts of unspliced viral genomic RNA could have an important function. Indeed, in murine cells, HIV transcripts are spliced excessively, a process that is not inhibited by the murine splicing inhibitor p32 (mp32). In marked contrast, its human counterpart, hp32, not only blocks this splicing but promotes the accumulation of viral… CONTINUE READING

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