Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-κB and NFAT signaling in tumor-associated T cells.

@article{SimpsonAbelson2013HumanOT,
  title={Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-κB and NFAT signaling in tumor-associated T cells.},
  author={Michelle R. Simpson-Abelson and Jenni L Loyall and Heather K. Lehman and Jennifer L. Barnas and Hans Minderman and Kieran L O'Loughlin and Paul K. Wallace and Thaddeus C. George and Peng Peng and Raymond J. Kelleher and Kunle O Odunsi and Richard B. Bankert},
  journal={Cancer immunity},
  year={2013},
  volume={13},
  pages={14}
}
Human memory T cells present in ovarian tumor ascites fluids fail to respond normally to stimulation via the T cell receptor (TCR). This immunosuppression is manifested by decreases in NF-κB and NFAT activation, IFN-γ production, and cell proliferation in response to TCR stimulation with immobilized antibodies to CD3 and CD28. The anergy of the tumor-associated T cells (TATs) is mediated by soluble factors present in ovarian tumor ascites fluids. The non-responsiveness of the T cells is quickly… CONTINUE READING
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www.cancerimmunity.org 7 of 10 Cancer Immunity

  • TC George, SL Fanning, +8 authors Morrissey
  • J Immunol Methods
  • 2013
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