Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins.

@article{Li2001HumanOC,
  title={Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins.},
  author={Julang Li and Qiang Feng and Jeong Mo Kim and Danielle Schneiderman and Peter Liston and Ming Li and Barbara C Vanderhyden and Wylam Faught and Michael Fung Kee Fung and Mary K. Senterman and R. G. Korneluk and Benjamin K-T Tsang},
  journal={Endocrinology},
  year={2001},
  volume={142 1},
  pages={370-80}
}
The inhibitor of apoptosis proteins (IAPs) constitutes a family of highly conserved apoptosis suppressor proteins that were originally identified in baculoviruses. Although IAP homologs have recently been demonstrated to suppress apoptosis in mammalian cells, their expression and role in human ovarian epithelial cancer and chemotherapy resistance are unknown. In the present study we used cisplatin-sensitive and -resistant human ovarian surface epithelial (hOSE) cancer cell lines and adenoviral… CONTINUE READING

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