Human ovarian 17-ketosteroid oxidoreductase: unique characteristics of the granulosa-luteal cell and stromal enzyme.

@article{Barbieri1992HumanO1,
  title={Human ovarian 17-ketosteroid oxidoreductase: unique characteristics of the granulosa-luteal cell and stromal enzyme.},
  author={Robert L. Barbieri},
  journal={American journal of obstetrics and gynecology},
  year={1992},
  volume={166 4},
  pages={1117-23; discussion 1123-6}
}
OBJECTIVES We attempted to test the hypothesis that distinct forms of the 17-ketosteroid oxidoreductase exist in the human ovary and to compare its activity in stroma obtained from normally cycling women and from hyperandrogenic women. STUDY DESIGN Human ovarian granulosa-luteal cell and stromal 17-ketosteroid oxidoreductase were examined in cell incubations and subcellular homogenates. RESULTS In subcellular homogenates of granulosa-luteal cells 17-ketosteroid oxidoreductase activity was… CONTINUE READING