Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin-8.

@article{Rothe1998HumanOA,
  title={Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin-8.},
  author={Linda Rothe and Patricia Collin-Osdoby and Yuxia Chen and Teresa Sunyer and Lala R. Chaudhary and Alfie Tsay and Steve Goldring and Louis Avioli and Philip A. Osdoby},
  journal={Endocrinology},
  year={1998},
  volume={139 10},
  pages={4353-63}
}
Chemokines, including interleukin-8 (IL-8), function as key mediators in diverse inflammatory disorders via promoting the recruitment, proliferation, and activation of vascular and immune cells. IL-8 levels are elevated in inflammatory diseases, such as rheumatoid arthritis, osteoarthritis, osteomyelitis, and periodontal disease, that also exhibit progressive bone loss. Therefore, it is possible that IL-8 contributes to the osteopenia associated with these pathological conditions. Although… CONTINUE READING

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