Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis.

@article{Fujikawa1996HumanOF,
  title={Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis.},
  author={Yasushi Fujikawa and Afsie Sabokbar and Susan D. Neale and Nicholas A Athanasou},
  journal={Annals of the rheumatic diseases},
  year={1996},
  volume={55 11},
  pages={816-22}
}
OBJECTIVE To determine whether synovial macrophages and monocytes isolated from patients with rheumatoid arthritis patients are capable of differentiating into osteoclastic bone resorbing cells; and the cellular and humoral conditions required for this to occur. METHODS Macrophages isolated from the synovium and monocytes from the peripheral blood of rheumatoid arthritis patients were cultured on bone slices and coverslips, in the presence and absence of UMR 106 rat osteoblast-like cells, 1… CONTINUE READING

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A point mutation in the extra cellular domain of the human CSF1 receptor ( cfms product ) activates its transforming potential

  • MF Roussel, Downing, CW Rettenmeier, CJ Sherr
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