Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and β‐N‐acetylhexosaminidase release

@article{Lisignoli2003HumanOE,
  title={Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and $\beta$‐N‐acetylhexosaminidase release},
  author={G. Lisignoli and S. Toneguzzi and A. Piacentini and L. Cattini and A. Lenti and M. Tschon and S. Cristino and F. Grassi and A. Facchini},
  journal={Journal of Cellular Physiology},
  year={2003},
  volume={194}
}
Osteoblasts (OBs) contribute to the maintenance of bone homeostasis and their activity can be influenced by immune cells localized in bone lacunae. We investigated the expression of the chemokine receptors in isolated human OBs by reverse transcriptase‐polymerase chain reaction (RT‐PCR) and flow cytometry, and report a novel finding, namely, that OBs express high levels of CXC chemokine receptor 3 (CXCR3) and 5 (CXCR5). Functional assays to evaluate CXCR3 and CXCR5 demonstrated that their… Expand
Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts
Role of CXC chemokine ligand 13 in oral squamous cell carcinoma associated osteolysis in athymic mice
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