Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization.

@article{Prasanth2010HumanOR,
  title={Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization.},
  author={Supriya Gangadharan Prasanth and Zhen Shen and Kannanganattu V Prasanth and Bruce W. Stillman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 34},
  pages={15093-8}
}
The origin recognition complex (ORC) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing, sister chromatid cohesion, telomere biology, heterochromatin localization, centromere and centrosome activity, and cytokinesis. We show that, in human cells, multiple ORC subunits associate with hetereochromatin protein 1 (HP1) alpha- and HP1beta-containing heterochromatic foci. Fluorescent bleaching studies indicate that multiple… CONTINUE READING

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The origin recognition complex ( ORC ) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing , sister chromatid cohesion , telomere biology , heterochromatin localization , centromere and centrosome activity , and cytokinesis .
The origin recognition complex ( ORC ) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing , sister chromatid cohesion , telomere biology , heterochromatin localization , centromere and centrosome activity , and cytokinesis .
The origin recognition complex ( ORC ) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing , sister chromatid cohesion , telomere biology , heterochromatin localization , centromere and centrosome activity , and cytokinesis .
The origin recognition complex ( ORC ) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing , sister chromatid cohesion , telomere biology , heterochromatin localization , centromere and centrosome activity , and cytokinesis .
The origin recognition complex ( ORC ) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing , sister chromatid cohesion , telomere biology , heterochromatin localization , centromere and centrosome activity , and cytokinesis .
The origin recognition complex ( ORC ) is a DNA replication initiator protein also known to be involved in diverse cellular functions including gene silencing , sister chromatid cohesion , telomere biology , heterochromatin localization , centromere and centrosome activity , and cytokinesis .
ORC1 geneGene encodes gene productORC1L protein, human
Direct binding of both Orc1 and Orc3 to HP1 suggests that , after the degradation of Orc1 at the G1/S boundary , Orc3 facilitates assembly of ORC / HP1 proteins to chromatin .
Direct binding of both Orc1 and Orc3 to HP1 suggests that , after the degradation of Orc1 at the G1/S boundary , Orc3 facilitates assembly of ORC / HP1 proteins to chromatin .
ORC1L protein, humanGene product is element in pathwayCell Cycle
Fluorescent bleaching studies indicate that multiple subcomplexes of ORC exist at heterochromatin , with Orc1 stably associating with heterochromatin in G1 phase , whereas other ORC subunits have transient interactions throughout the cell - division cycle .
Direct binding of both Orc1 and Orc3 to HP1 suggests that , after the degradation of Orc1 at the G1/S boundary , Orc3 facilitates assembly of ORC / HP1 proteins to chromatin .
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