Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells.

@article{Chiba2013HumanOC,
  title={Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells.},
  author={Shoetsu Chiba and Toru Ikawa and Hiroshi Takeshita and Sanae Kanno and Tomonori Nagai and Meri Takada and Toshiji Mukai and Michael F. Wempe},
  journal={Toxicology},
  year={2013},
  volume={310},
  pages={98-103}
}
Highly expressed in kidney and located on the basolateral membrane, human organic cation transporter 2 (hOCT2) can transport various compounds (i.e. drugs and toxins) into the proximal tubular cell. Using cultured proximal tubule cells stably expressing hOCT2 (i.e. S2-hOCT2 cells), we sought to probe different compound classes (e.g. analgesics, anti-depressants, anti-psychotics, disinfectant, herbicides, insecticides, local anesthetic, muscarinic acetylcholine receptor antagonist, sedatives… CONTINUE READING