Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.

@article{Mahagita2007HumanOA,
  title={Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.},
  author={Chitrawina Mahagita and Steven M. Grassl and Pawinee Piyachaturawat and Nazzareno Ballatori},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={293 1},
  pages={
          G271-8
        }
}
Organic anion transporting polypeptides (OATP/SLCO) are generally believed to function as electroneutral anion exchangers, but direct evidence for this contention has only been provided for one member of this large family of genes, rat Oatp1a1/Oatp1 (Slco1a1). In contrast, a recent study has indicated that human OATP1B3/OATP-8 (SLCO1B3) functions as a GSH-bile acid cotransporter. The present study examined the transport mechanism and possible GSH requirement of the two members of this protein… CONTINUE READING

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