Human orbital fibroblasts in culture bind and respond to endothelin.

@article{Smith1993HumanOF,
  title={Human orbital fibroblasts in culture bind and respond to endothelin.},
  author={Terry J. Smith and R J Kottke and Hazel Lum and Thomas T. Andersen},
  journal={The American journal of physiology},
  year={1993},
  volume={265 1 Pt 1},
  pages={C138-42}
}
Human fibroblasts in primary cell culture were studied for their ability to bind to endothelin (ET), a 21-amino acid peptide with profound vasoconstricting properties. When 125I-labeled ET-1 was incubated with confluent orbital fibroblasts in the presence of increasing concentrations of unlabeled ligand, a single class of binding site was defined with a… CONTINUE READING