• Corpus ID: 24436695

Human optic nerve fiber count and optic disc size.

  title={Human optic nerve fiber count and optic disc size.},
  author={Jost Bruno Jonas and Andreas M. Schmidt and J A M{\"u}ller-Bergh and Ursula Schl{\"o}tzer-Schrehardt and Gottfried O. H. Naumann},
  journal={Investigative ophthalmology \& visual science},
  volume={33 6},
In the optic nerve head, the optic nerve fibers are represented by the neuroretinal rim. The rim area showing a high interindividual variability is positively correlated with the optic disc size. This study was performed to address the question of whether, in addition to having a larger neuroretinal rim, eyes with large optic discs also have a higher count of optic nerve fibers compared to eyes with small optic nerve heads. Histologic semithin sections of 72 optic nerves of 56 cornea donors… 
Optic nerve fiber count and diameter of the retrobulbar optic nerve in normal and glaucomatous eyes
The optic nerve fiber count can be estimated in routine histology by measuring the optic nerve diameter using this linear regression equation, and greater retrobulbar optic nerve caliber may indicate greater structural reserve capacity.
Retinal nerve fiber layer thickness in human eyes
In normal eyes, the RNFL shows a double hump configuration with its thinnest part at the temporal disc pole, followed by the nasal disc pole and the superior disc Pole, while in absolute glaucoma, RNFL is thickest at the inferior disc pole.
Retinal Nerve Fiber Layer Converges More Convexly on Normal Smaller Optic Nerve Head
It is demonstrated that the shape of the RNFLs converging “on” and entering “into” the optic disc was more convex for small optic discs compared with large discs, which may guide the clinical evaluation of glaucomatous ONH damage.
The Normal Optic Nerve Head
Over the past 30 years, technology has allowed for changing views about what may be considered normal in reference to the optic nerve head, and this information is valuable to the eye care practitioner in helping to make appropriate patient care management decisions.
Optic disc size and optic nerve damage in normal pressure glaucoma.
The results indicate that for a given patient the degree of glaucomatous optic nerve atrophy was not markedly associated with the optic disc size, and the finding that patients with large visual field defects had smaller discs than patients with moderate perimetric loss may indicate that the results of previous cross sectional studies reporting on an unusually large disc size in normal pressureglaucoma may be due partially to selection.
Optic nerve head topographic measurements and retinal nerve fiber layer thickness in physiologic large cups.
HRT ONH parameters and RNFL thickness obtained with OCT may be useful for differentiating between glaucoma and LC eyes.
Larger optic nerve heads have more nerve fibers in normal monkey eyes.
The cup-to-disc ratio and the neural rim area are used to detect glaucoma damage to the optic nerve and the number of nerve fibers increased linearly with an increasing disc area.
Age-related changes in the human optic nerve.
Optic disc morphology in eyes after nonarteritic anterior ischemic optic neuropathy.
  • J. Jonas, L. Xu
  • Medicine
    Investigative ophthalmology & visual science
  • 1993
The results indicate that the parapapillary chorioretinal atrophy is not larger in eyes after nonarteritic AION compared with normal eyes, and show that the area and shape of the neuroretinal rim, as determined planimetrically, may not markedly change after nonartersitic Aion.


Histomorphometry of the human optic nerve.
The age-dependent nerve fiber loss, among other factors, may partially explain the decreased visual performance of older subjects and should be considered in progression and "pseudoprogression" of optic nerve diseases like glaucoma.
The number and diameter distribution of axons in the monkey optic nerve.
The observation that higher fiber density and smaller mean fiber diameter are skewed toward the inferior pole appears to coincide with the inferior position of the fovea with respect to the optic nerve head has importance for interpretation of pathologic changes in the optic disc.
Chronic glaucoma selectively damages large optic nerve fibers.
Fibers larger than the normal mean diameter atrophied more rapidly in glaucomatous eyes, though no fiber size was spared from damage, and larger fibers were lost preferentially even in areas of the optic nerve with mild damage, indicating their inherent susceptibility to injury byglaucoma.
Racial differences in optic nerve head parameters.
A mathematical model of the optic disc is derived that relates posterior displacement of the lamina cribrosa to the disc area, distensibility of the disc, and intraocular pressure and there was no difference in the disc rim area between the two groups.
Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes.
Four hundred and fifty-seven unselected normal human optic nerve heads of 319 subjects were evaluated by magnification-corrected morphometry of optic disc photographs, finding that the cup was significantly larger in discs with steep "punched-out" cups and neuroretinal rim area was broadest in the inferior optic disc region.
Optic nerve damage in Alzheimer's disease.