Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent delta-opioid pathways.

@article{Javelot2010HumanOI,
  title={Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent delta-opioid pathways.},
  author={Herv{\'e} Javelot and Micha{\"e}l Messaoudi and Sophie Garnier and Catherine Rougeot},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2010},
  volume={61 3},
  pages={
          355-62
        }
}
Human opiorphin protects enkephalins from degradation by human neutral endopeptidase and aminopeptidase-N and inhibits pain perception in various behavioral rodent models of pain via endogenous enkephalin-related activation of opioidergic pathways. In addition to pain control, endogenous opioid pathways are also implicated in the modulation of emotion-related behaviors. Thus, we explored the dose-dependent motivational responses induced by opiorphin using the forced swim test, the standard rat… CONTINUE READING
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