Human opioid receptors: chromosomal mapping and mRNA localization.

@article{Miotto1996HumanOR,
  title={Human opioid receptors: chromosomal mapping and mRNA localization.},
  author={K Miotto and Daniel L. Kaufman and Benito Ant{\'o}n and Duane E. Keith and Christopher J. Evans},
  journal={NIDA research monograph},
  year={1996},
  volume={161},
  pages={
          72-82
        }
}
The opioid system modulates complex processes such as neuroendocrine function, analgesia, immunity, and cardiovascular regulation. A challenge in the field of neuroscience has been the molecular characterization of the opioid receptors. The recent isolation and sequencing of the genes and cDNAs encoding the opioid receptors permit studies of structure, function, and the cellular localization of these receptors. This chapter describes recent studies on the characterization and chromosomal… 
View on PubMed
archives.drugabuse.gov
9 Citations
Background Citations
2

Tables from this paper

9 Citations

Opioid receptor regulation

  • M. Zastrow
  • Biology, Medicine
    NeuroMolecular Medicine
  • 2007
Cell biological studies using cultured heterologous cell models and primary cultures of central nervous system neurons have identified multiple subcellular locations at which specific aspects of opioid receptor signaling and membrane trafficking are regulated.

Alcohol and gene expression in the central nervous system.

Although functional genomic experiments (transcriptome analysis) have failed to identify a single alcoholism gene, they have illuminated important pathways and gene products that may contribute to the risk of alcohol abuse and alcoholism.

REVIEW ALCOHOL AND GENE EXPRESSION IN THE CENTRAL NERVOUS SYSTEM

Although functional genomic experiments (transcriptome analysis) have failed to identify a single alcoholism gene, they have illuminated important pathways and gene products that may contribute to the risk of alcohol abuse and alcoholism.

Chapter Seven – The Neuropathology of Drug Abuse

Central Nervous System Alterations in Drug Abuse

Based on animal experiments, the abuse of amphetamine, methamphetamine, and 3,4-methylenedioxymethamphetamine (MDMA) has been related to neurotoxicity in human long-term abusers and to the risk of developing Parkinson’s disease.

A pilot study assessing fentanyl dose requirements in opioid-maintained individuals.

This document summarizes the findings of a two-year study into the determinants of infectious disease in eight operation rooms of the immune system and some of the mechanisms leading to disease and its consequences.

Neuropathology of Drug Abuse

Basic Substance Characteristics and Neuropathological Findings in Drug Abusers

STUDIES ON K-OPIOID RECEPTOR EXPRESSION IN CELL CULTURES AND HUMAN CORTEX

References

SHOWING 1-10 OF 55 REFERENCES

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

cDNA cloning and regional distribution of a novel member of the opioid receptor family

Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes.

RNA blot hybridization analysis revealed that cerebrum and brainstem contain both ROR-A and R OR-B mRNAs, whereas neither ROR/ROR-B can be detected in cerebellum, and the ligand-binding properties of R OR/B expressed from the cloned cDNAs in Chinese hamster ovary cells correspond most closely to those of the pharmacologically defined delta- and mu-opioid receptor subtypes.

Molecular cloning and functional expression of a mu opioid receptor from rat brain

Identification of a human delta opioid receptor: cloning and expression.

Isolation of a Human κ Opioid Receptor cDNA from Placenta

By using a mouse δ opioid receptor cDNA as a probe, a κ opioid receptor gene was isolated from a human genomic library. Reverse transcriptase/PCR was subsequently used to isolate the corresponding…

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type.

In situ hybridization analysis revealed that LC132 mRNA is highly expressed in several rat brain areas, including the cerebral cortex, thalamus, subfornical organ, habenula, hypothalamus, central gray, dorsal raphe, locus coeruleus and the dorsal horn of the spinal cord.

Central Distribution of Opioid Receptors: A Cross-Species Comparison of the Multiple Opioid Systems of the Basal Ganglia

The basal ganglia provide a neuroanatomical system that is well defined anatomically, in terms of the basic units which comprise it, demonstrates complex neurotransmitter-receptor interactions, and has been functionally implicated in sensory-motor integration and motivated behaviors.

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization.

A random primed expression cDNA library was constructed from the RNA of NG 108-15 cells that encodes a 371-amino acid-residue protein presenting all the structural characteristics of receptors that interact with guanine nucleotide-binding proteins.
...