Human oocytes reversibly arrested in prophase I by phosphodiesterase type 3 inhibitor in vitro.

Abstract

This study addresses the role of cAMP hydrolytic isoenzyme phosphodiesterase type 3 (PDE 3) modulation on human oocyte maturation in vitro. Presence of phosphodiesterase type 3 A (PDE 3A) mRNA was confirmed in human germinal vesicle-stage (GV) oocytes. Making use of a selective PDE 3 inhibitor, Org 9935 (10 microM), oocytes retrieved from immature follicles… (More)

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@article{Nogueira2003HumanOR, title={Human oocytes reversibly arrested in prophase I by phosphodiesterase type 3 inhibitor in vitro.}, author={Daniela Nogueira and Carola Albano and Tom Adriaenssens and Rita G Cortvrindt and Claire Bourgain and Paul Devroey and Johan E J Smitz}, journal={Biology of reproduction}, year={2003}, volume={69 3}, pages={1042-52} }