Human oocytes reprogram somatic cells to a pluripotent state

@article{Noggle2011HumanOR,
  title={Human oocytes reprogram somatic cells to a pluripotent state},
  author={Scott A. Noggle and Ho-Lim Fung and Athurva Jayavant Gore and Hector Martinez and K. C. Satriani and Robert W. Prosser and K. B Oum and Daniel Paull and Sarah Druckenmiller and Matthew Freeby and Ellen Greenberg and Kun Zhang and Robin Goland and Mark V. Sauer and Rudolph L. Leibel and Dieter Egli},
  journal={Nature},
  year={2011},
  volume={478},
  pages={70-75}
}
The exchange of the oocyte’s genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cells affected in degenerative human diseases. Such cells, carrying the patient’s genome, might be useful for cell replacement. Here we report that the development of human oocytes after genome exchange arrests at late cleavage stages in association with transcriptional abnormalities. In contrast, if the oocyte genome is not removed… 

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