Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

  title={Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells},
  author={M. Yamada and B. Johannesson and I. Sagi and L. Burnett and D. Kort and R. Prosser and D. Paull and Michael W. Nestor and M. Freeby and Ellen Greenberg and R. Goland and R. Leibel and Susan L. Solomon and N. Benvenisty and M. Sauer and D. Egli},
  • M. Yamada, B. Johannesson, +13 authors D. Egli
  • Published 2014
  • Biology, Medicine
  • Nature
  • The transfer of somatic cell nuclei into oocytes can give rise to pluripotent stem cells that are consistently equivalent to embryonic stem cells, holding promise for autologous cell replacement therapy. Although methods to induce pluripotent stem cells from somatic cells by transcription factors are widely used in basic research, numerous differences between induced pluripotent stem cells and embryonic stem cells have been reported, potentially affecting their clinical use. Because of the… CONTINUE READING
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