Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

@article{Yamada2014HumanOR,
  title={Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells},
  author={M. Yamada and B. Johannesson and I. Sagi and L. Burnett and D. Kort and R. Prosser and D. Paull and Michael W. Nestor and M. Freeby and Ellen Greenberg and R. Goland and R. Leibel and Susan L. Solomon and N. Benvenisty and M. Sauer and D. Egli},
  journal={Nature},
  year={2014},
  volume={510},
  pages={533-536}
}
  • M. Yamada, B. Johannesson, +13 authors D. Egli
  • Published 2014
  • Biology, Medicine
  • Nature
  • The transfer of somatic cell nuclei into oocytes can give rise to pluripotent stem cells that are consistently equivalent to embryonic stem cells, holding promise for autologous cell replacement therapy. Although methods to induce pluripotent stem cells from somatic cells by transcription factors are widely used in basic research, numerous differences between induced pluripotent stem cells and embryonic stem cells have been reported, potentially affecting their clinical use. Because of the… CONTINUE READING
    152 Citations
    Stem cells: The quest for the perfect reprogrammed cell
    • 7
    From cloned frogs to patient matched stem cells: induced pluripotency or somatic cell nuclear transfer?
    • 6
    Pluripotent Stem Cells, Endogenous versus Reprogrammed, a Review
    • 11
    • PDF
    The role of the reprogramming method and pluripotency state in gamete differentiation from patient-specific human pluripotent stem cells
    • 11
    • Highly Influenced
    Derivation and differentiation of haploid human embryonic stem cells
    • 81
    • PDF

    References

    SHOWING 1-10 OF 38 REFERENCES
    Human oocytes reprogram somatic cells to a pluripotent state
    • 135
    • PDF
    Nuclear transfer into mouse oocytes.
    • D. Egli, K. Eggan
    • Biology, Medicine
    • Journal of visualized experiments : JoVE
    • 2006
    • 8
    • PDF
    Epigenetic memory in induced pluripotent stem cells
    • 1,945
    • PDF
    Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells
    • 150
    • PDF
    Somatic coding mutations in human induced pluripotent stem cells
    • 1,102
    • PDF
    Reprogramming within hours following nuclear transfer into mouse but not human zygotes.
    • 68
    • PDF