Human olfactory receptor responses to odorants

  title={Human olfactory receptor responses to odorants},
  author={Joel D Mainland and Yun Rose Li and Ting Zhou and Wen Ling L. Liu and Hiroaki Matsunami},
  booktitle={Scientific data},
Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a… CONTINUE READING
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