Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics.

@article{BorgmannWinter2009HumanOE,
  title={Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics.},
  author={Karin E. Borgmann-Winter and Nancy E. Rawson and Hoau-Yan Wang and Mathew L Macdonald and Mehmet Hakan Ozdener and Karen K Yee and Gimena Gomez and J Xu and Bruce Bryant and Grzegorz Adamek and Natasha Arjumand Shoaib Mirza and Edmund A. Pribitkin and C G Hahn},
  journal={Neuroscience},
  year={2009},
  volume={158 2},
  pages={642-53}
}
The olfactory epithelium constitutes the sole source of regenerating neural cells that can be obtained from a living human. As such, primary cultures derived from human olfactory epithelial biopsies can be utilized to study neurobiological characteristics of individuals under different conditions and disease states. Here, using such human cultures, we report in vitro generation of cells that exhibit a complex neuronal phenotype, encompassing receptors and signaling pathways pertinent to both… CONTINUE READING