Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity.

@article{Reynolds2004HumanNE,
  title={Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity.},
  author={Mindy F Reynolds and Elizabeth J Peterson and George Quievryn and Anatoly Zhitkovich},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 29},
  pages={30419-24}
}
Intracellular reduction of carcinogenic Cr(VI) leads to the extensive formation of Cr(III)-DNA phosphate adducts. Repair mechanisms for chromium and other DNA phosphate-based adducts are currently unknown in human cells. We found that nucleotide excision repair (NER)-proficient human cells rapidly removed chromium-DNA adducts, with an average t((1/2)) of 7.1 h, whereas NER-deficient XP-A, XP-C, and XP-F cells were severely compromised in their ability to repair chromium-DNA lesions. Activation… CONTINUE READING

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