Human neutrophils produce interferon gamma upon stimulation by interleukin-12

  title={Human neutrophils produce interferon gamma upon stimulation by interleukin-12},
  author={Fr{\'e}d{\'e}ric Ethuin and B{\'e}n{\'e}dicte G{\'e}rard and Jamel El Benna and Anne Boutten and Marie-Anne Gougereot-Pocidalo and Laurent Jacob and Sylvie Chollet-Martin},
  journal={Laboratory Investigation},
Interferon γ (IFNγ) is a Th1 cytokine mainly produced by T cells, NK cells and macrophages in response to interleukin (IL)-12. As polymorphonuclear neutrophils (PMN) have been shown to produce and to release numerous cytokines, in particular upon IL-12 stimulation, we investigated the ability of highly purified PMN to secrete IFNγ. We found that PMN contained a small store of IFNγ, and that this store was rapidly secreted upon stimulation by degranulating agents such as formyl peptides… CONTINUE READING
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