Human neutrophils employ chlorine gas as an oxidant during phagocytosis.

  title={Human neutrophils employ chlorine gas as an oxidant during phagocytosis.},
  author={Stanley L. Hazen and Fong Fu Hsu and Dianne M Mueller and Jan R. Crowley and Jay W. Heinecke},
  journal={The Journal of clinical investigation},
  volume={98 6},
Reactive oxidants generated by phagocytes are of central importance in host defenses, tumor surveillance, and inflammation. One important pathway involves the generation of potent halogenating agents by the myeloperoxidase-hydrogen peroxide-chloride system. The chlorinating intermediate in these reactions is generally believed to be HOCl or its conjugate base, ClO-. However, HOCl is also in equilibrium with Cl2, raising the possibility that Cl2 executes oxidation/ halogenation reactions that… CONTINUE READING


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