Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.

@article{Salvemini1989HumanNA,
  title={Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.},
  author={Daniela Salvemini and Gilberto De Nucci and Ryszard Jerzy Gryglewski and John R. Vane},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 16},
  pages={6328-32}
}
Incubation of neutrophils or mononuclear cells with washed platelets (all prepared from human venous blood) resulted in an inhibition of thrombin-induced platelet aggregation that was dependent on the number of nucleated cells added. The inhibition was potentiated by superoxide dismutase and reversed by oxyhemoglobin. In the case of neutrophils the inhibition was associated with an increase in cGMP, whereas with mononuclear cells both cAMP and cGMP were increased. The inhibitory activity of… CONTINUE READING