Human neutrophil plasminogen activator is localized in specific granules and is translocated to the cell surface by exocytosis


The subcellular localization of plasminogen activator (PA) in human neutrophils was studied. The cells were disrupted by nitrogen cavitation and fractionated on Percoll density gradients into three major components containing the plasma membranes, the specific granules, and the azurophilic granules. The biochemical markers we used to identify these… (More)


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