Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases.

@article{Quinn2008HumanNP,
  title={Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases.},
  author={Kieran L Quinn and Melanie Henriques and Tom Parker and Arthur S Slutsky and Haibo Zhang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 5},
  pages={H1817-24}
}
The traditional view of atherosclerosis has recently been expanded from a predominantly lipid retentive disease to a coupling of inflammatory mechanisms and dyslipidemia. Studies have suggested a novel role for polymorphonuclear neutrophil (PMN)-dominant inflammation in the development of atherosclerosis. Human neutrophil peptides (HNPs), also known as alpha-defensins, are secreted and released from PMN granules upon activation and are conventionally involved in microbial killing. Current… CONTINUE READING

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