Human neutrophil peptide-1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiols.

@article{McDaniel2019HumanNP,
  title={Human neutrophil peptide-1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiols.},
  author={Jenny K. McDaniel and Mohammad S. Abdelgawwad and Audra A Hargett and Matthew B Renfrow and Khalil H Bdeir and Wenjing Cao and Douglas B Cines and X Long Zheng},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2019},
  volume={17 4},
  pages={
          596-606
        }
}
Essentials Biological activity of human neutrophil peptide (HNP)-1 in hemostasis under physiological conditions is not fully understood. HNP-1 inhibits the adhesion/aggregation of murine platelets on a fibrillar collagen surface or an activated endothelial cell surface under flow. The anti-adhesion activity appears to depend on the terminal free thiols of HNP-1, which may inhibit VWF-VWF lateral associations. Our results suggest a protective role and potential novel therapeutic use of HNP-1 for… CONTINUE READING
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