Human neutrophil collagenase cleaves alpha 1-antitrypsin.

  title={Human neutrophil collagenase cleaves alpha 1-antitrypsin.},
  author={Jacqueline Michaelis and Margret C. M. Vissers and Christine C Winterbourn},
  journal={The Biochemical journal},
  volume={270 3},
Inactivation of the plasma serine-proteinase inhibitor alpha 1-antitrypsin (alpha 1-AT) by neutrophil metalloproteinases has been reported [Vissers, George, Bathurst, Brennan & Winterbourn (1987) Fed. Proc. Fed. Am. Soc. Exp. Biol. 46, 1390a; (1988) J. Clin. Invest. 82, 706-711; Desrochers & Weiss (1988) J. Clin. Invest. 81, 1646-1650]. To identify the enzyme responsible, supernatant from neutrophils stimulated with phorbol 12-myristate 13-acetate was subjected to preparative SDS/PAGE, both… CONTINUE READING


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