Human neutrophil cathepsin G down-regulates LPS-mediated monocyte activation through CD14 proteolysis.

@article{LeBarillec2000HumanNC,
  title={Human neutrophil cathepsin G down-regulates LPS-mediated monocyte activation through CD14 proteolysis.},
  author={Karine Le-Barillec and Dominique Pidard and Viviane Balloy and Michel Chignard},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={68 2},
  pages={209-15}
}
A major property of monocytes/macrophages is to recognize and to be activated by bacterial wall components such as LPS, through membrane receptors including the key element CD14. We demonstrate that CD14 expression is down-regulated, as judged by flow cytometry analysis, upon incubation of human monocytes with purified cathepsin G (CG), a releasable neutrophil serine proteinase. The progressive decrease of CD14 expression due to increasing concentrations of CG highly correlates (P < 0.0001… CONTINUE READING

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