Human neutrophil antimicrobial activity.

@article{Thomas1988HumanNA,
  title={Human neutrophil antimicrobial activity.},
  author={Elaine L. Thomas and Robert I. Lehrer and Richard F. Rest},
  journal={Reviews of infectious diseases},
  year={1988},
  volume={10 Suppl 2},
  pages={S450-6}
}
Polymorphonuclear neutrophilic leukocytes (PMNs) take up opsonized microorganisms into phagosomes that fuse with secretory granules in the PMN cytoplasm to form phagolysosomes. Killing and digestion of microorganisms take place within phagolysosomes. Antimicrobial activities in phagolysosomes are divided into two classes. Oxygen (O2)-dependent mechanisms are expressed when PMNs undergo the "respiratory burst." An NADPH oxidase in the phagolysosome membrane is activated and reduces O2 to… CONTINUE READING
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