Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function.

@article{Ding2005HumanNY,
  title={Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function.},
  author={Bo Ding and Bj{\"o}rn Kull and Zhurong Liu and Salim Mottagui-Tabar and H{\aa}kan Thonberg and Harvest F Gu and Anthony J. Brookes and Lars Grundemar and Christina Karlsson and Anders Hamsten and Peter Arner and C. G. Ostenson and Suad Efend{\'i}c and Magnus Monn{\'e} and Gunnar von Heijne and Per Eriksson and Claes Wahlestedt},
  journal={Regulatory peptides},
  year={2005},
  volume={127 1-3},
  pages={45-53}
}
Neuropeptide Y (NPY) has been implicated in the control of food intake and energy balance based on many observations in animals. We have studied single nucleotide polymorphisms (SNPs) within the regulatory and coding sequences of the human NPY gene. One variant (1128 T>C), which causes an amino acid change from leucine to proline at codon 7 in the signal peptide of NPY, was associated with increased body mass index (BMI) in two separate Swedish populations of normal and overweight individuals… CONTINUE READING