Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling.

@article{Matsui1993HumanNC,
  title={Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling.},
  author={Tamano Matsui and Kunio Sano and Tatsuo Tsukamoto and Masaaki Ito and Toshiaki Takaishi and Hiroyasu Nakata and H. Richard Nakamura and Kazuo Chihara},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 3},
  pages={1153-60}
}
Both platelet-derived growth factor (PDGF) A- and B-chains are expressed in mammalian neurons, but their precise roles still remain to be clarified. In the present studies, we examined the expression of two PDGF receptor genes in human tumor cell lines derived from neural crest. The expression of alpha and/or beta PDGF receptors was detected in a wide variety of neural crest-derived human tumor cell lines such as neuroblastoma, primitive neuroectodermal tumor, and Ewing's sarcoma by RNA blot… CONTINUE READING

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