Human neuroblastoma cell lines as models of catechol uptake.

  title={Human neuroblastoma cell lines as models of catechol uptake.},
  author={Mark L. Richards and Wolfgang Sadee},
  journal={Brain research},
  volume={384 1},
This report compares the effect of antidepressants on the accumulation of [3H]catecholamines in two human neuroblastoma cell lines, IMR-32 and SK-N-SH, and a rat pheochromocytoma cell line, PC-12. Analysis of the catecholamine uptake system in SK-N-SH cells revealed that both [3H]dopamine and [3H]norepinephrine accumulated via a single competitive, saturable and apparently active process. Similar potencies exhibited by several inhibitors suggest that identical uptake systems exist in all 3 cell… CONTINUE READING
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