Human neural tube defects: developmental biology, epidemiology, and genetics.

  title={Human neural tube defects: developmental biology, epidemiology, and genetics.},
  author={Eric R Detrait and Timothy Merrill George and Heather C Etchevers and John R. Gilbert and Michel Vekemans and Marcy C. Speer},
  journal={Neurotoxicology and teratology},
  volume={27 3},
Birth defects (congenital anomalies) are the leading cause of death in babies under 1 year of age. Neural tube defects (NTD), with a birth incidence of approximately 1/1000 in American Caucasians, are the second most common type of birth defect after congenital heart defects. The most common presentations of NTD are spina bifida and anencephaly. The etiologies of NTDs are complex, with both genetic and environmental factors implicated. In this manuscript, we review the evidence for genetic… CONTINUE READING
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