Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease

@article{Bjugstad2008HumanNS,
  title={Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease},
  author={Kimberly B Bjugstad and Yang Dong Teng and Donald Eugene Redmond and John David Elsworth and John R. Sladek},
  journal={Experimental Neurology},
  year={2008},
  volume={211},
  pages={362-369}
}
Although evidence of damage-directed neural stem cell (NSC) migration has been well-documented in the rodent, to our knowledge it has never been confirmed or quantified using human NSC (hNSC) in an adult non-human primate modeling a human neurodegenerative disease state. In this report, we attempt to provide that confirmation, potentially advancing basic stem cell concepts toward clinical relevance. hNSCs were implanted into the caudate nucleus (bilaterally) and substantia nigra (unilaterally… CONTINUE READING
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