Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates.

  title={Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates.},
  author={Stefano Pluchino and Angela Pesenti Gritti and E. H. M. Blezer and Stefano Amadio and Elena Marta Brambilla and Giovanna Borsellino and Chiara Cossetti and Ubaldo del Carro and Giancarlo Comi and Bert A 't Hart and Angelo L. Vescovi and Gianvito Martino},
  journal={Annals of neurology},
  volume={66 3},
OBJECTIVE Transplanted neural stem/precursor cells (NPCs) display peculiar therapeutic plasticity in vivo. Although the replacement of cells was first expected as the prime therapeutic mechanism of stem cells in regenerative medicine, it is now clear that transplanted NPCs simultaneously instruct several therapeutic mechanisms, among which replacement of cells might not necessarily prevail. A comprehensive understanding of the mechanism(s) by which NPCs exert their therapeutic plasticity is… CONTINUE READING
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