Human neural progenitor cells show functional neuronal differentiation and regional preference after engraftment onto hippocampal slice cultures.

@article{Morgan2012HumanNP,
  title={Human neural progenitor cells show functional neuronal differentiation and regional preference after engraftment onto hippocampal slice cultures.},
  author={P Jeffrey Morgan and Andrea Liedmann and Rayk H{\"u}bner and Marine Hovakimyan and Arndt Rolfs and Moritz J Frech},
  journal={Stem cells and development},
  year={2012},
  volume={21 9},
  pages={1501-12}
}
The transplantation of stem cells offers potential therapies for many neurodegenerative disorders that currently have limited or no treatment options. However, relatively little is known about how the host environment affects the development and integration of these cells. In this study we have engrafted immortalized human midbrain neural progenitor cells (NPCs) onto rat hippocampal brain slice cultures to examine the influence of a neural environment on differentiation. Patch clamp recordings… CONTINUE READING