Human nerve growth factor sensitizes masseter muscle nociceptors in female rats

@article{Svensson2010HumanNG,
  title={Human nerve growth factor sensitizes masseter muscle nociceptors in female rats},
  author={Peter Svensson and Mian Wei Wang and X Dong and Ujendra Kumar and Brian Edwin Cairns},
  journal={PAIN®},
  year={2010},
  volume={148},
  pages={473-480}
}
Injection of nerve growth factor (NGF) into the masseter muscle is not painful but does induce a localized, quick onset ( approximately 1h) and long-lasting mechanical sensitization in healthy human subjects. We tested the hypothesis that human NGF mechanically sensitizes masseter muscle nociceptors by increasing the sensitivity of peripheral N-methyl-d-aspartate (NMDA) receptors. Co-expression of the NR2B subunit of the NMDA receptor with P75 and TrkA NGF receptors by trigeminal ganglion… CONTINUE READING

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